Targeting fundamentals of inflammation, autoimmunity and fibrosis

  • TRANSFORM

    inflammatory, autoimmune and fibrotic diseases

  • DIFFERENTIATE

    by targeting emerging central disease biology nodes

  • IMPACT

    via selective depletion of pathogenic cells

Chronic inflammatory diseases represent the most significant cause of death globally. Patients with autoimmune, inflammatory and fibrotic conditions are lacking efficacious treatment options. Granite Bio’s first-in-class assets are designed to target fundamental disease biology.

  • Granite Bio - GRT-001

    GRT-001

    Novel Mode of Action: Depletion of pathogenic pro-inflammatory monocytes via ADCC/ADCP. First-in-class »Innate Rituximab«.

  • Granite Bio – GRT-002

    GRT-002

    Novel Therapeutic Target: Proprietary patient profiling identified novel disease biology node in inflammation, autoimmunity and fibrosis.

Two first-in-class therapeutic antibodies GRT-001 and GRT-002

2000

20 years of foundational research

In novel approaches for inflammation and fibrosis

2021

Lead assets and pipeline growth

Foundation of Granite Bio by Versant Ventures and Novartis Venture Fund (NVF), integrated into the Ridgeline Discovery Engine. 30 Million USD Series A Financing


2022

Preclinical Development/CMC

Development Candidates achieved.


2023

Series B & CTA submission

70 Million USD Series B Financing led by Forbion and Sanofi ventures, completion of CTA enabling studies and CTA submission.



2024

Phase 1 / 1b

Clinical trial approval by the German health authorities (Paul-Ehrlich-Institute, PEI) to initiate Ph1(b) trial of GRT-001 in healthy volunteers and patients with inflammatory bowel disease (IBD). First Ph1 participants dosed March 6 at CRO Charité Berlin, Germany.

About Granite Bio:

Team:

Granite Bio Team:

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Ridgeline Team (supporting Granite Bio):

Board of Directors:

Scientific Advisors:

  • Vishwa Deep Dixit

    Yale University
    Innate Immunity

  • Christopher Denton

    University College London
    Fibrosis

  • Jörg Distler

    Düsseldorf University
    Fibrosis

  • Erica Herzog

    Yale University
    Pulmonary Fibrosis

  • Brian Feagan

    Ontario, Canada
    Inflammatory Bowel Disease

  • Florian Rieder

    Cleveland Clinic
    Inflammatory Bowel Disease

  • Scott Brian Snapper

    Boston/Harvard University
    Inflammatory Bowel Disease

  • Eric Solary

    Paris - Saclay University
    Leukemia (CMML)